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[Preprint]. 2023 Sep 26:2023.09.25.23295897. [Version 1] doi: 10.1101/2023.09.25.23295897

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Figure 5: — Quantification of ⁶⁸Ga-CBP8 in human tissue with RILI. H&E and trichrome stains of non-irradiated (top) and irradiated lung (bottom) with characteristic RILI changes including cellular infiltration, alveolar wall thickening, and increased collagen deposition (A). Autoradiography following incubation with ⁶⁸Ga-ctrl shows similar uptake between irradiated and non-irradiated lung tissue (upper panels). ⁶⁸Ga-CBP8 has increased uptake in irradiated vs non-irradiated lung tissue (lower panels) (B). ⁶⁸Ga-CBP8 intensity normalized to ⁶⁸Ga-ctrl signal intensity is significantly increased in irradiated tissue p=0.021 (C) and is significantly correlated with CPA p=0.026 (D), but not with hydroxyproline (E).