Table 2.

Association of lipid polygenic scores with observed lipid levels stratified by the fish oil intake status in UKB participants of European ancestry using GWAS summary statistics from Graham SE et al. (excluded UKB)^a

Lipids	Fish oil intake			No fish oil intake			${\mathit{P}}_{\mathbf{interaction}}$ b
	n	$\mathit{\beta }$ (95% CI)	P-value	n	$\mathit{\beta }$ (95% CI)	P-value
Total cholesterol, SD
Partially adjusted associationc	128634	0.244 (0.239, 0.249)	<2.0×10−16	276134	0.265 (0.261, 0.268)	<2.0×10−16	9.98×10−12
Fully adjusted associationd	103738	0.304 (0.299, 0.309)	<2.0×10−16	222391	0.313 (0.310, 0.317)	<2.0×10−16	3.53×10−4
LDL cholesterol, SD
Partially adjusted associationc	128393	0.262 (0.257, 0.267)	<2.0×10−16	275625	0.280 (0.277, 0.284)	<2.0×10−16	6.27×10−9
Fully adjusted associationd	103538	0.323 (0.318, 0.328)	<2.0×10−16	221994	0.332 (0.328, 0.335)	<2.0×10−16	0.001
HDL cholesterol, SD
Partially adjusted associationc	117709	0.235 (0.230, 0.240)	<2.0×10−16	252786	0.230 (0.227, 0.234)	<2.0×10−16	0.139
Fully adjusted associationd	94880	0.234 (0.229, 0.240)	<2.0×10−16	203514	0.227 (0.224, 0.231)	<2.0×10−16	0.025
Triglycerides, SD
Partially adjusted associationc	128544	0.252 (0.247, 0.257)	<2.0×10−16	275897	0.265 (0.262, 0.269)	<2.0×10−16	2.45×10−5
Fully adjusted associationd	103674	0.254 (0.248, 0.259)	<2.0×10−16	222215	0.267 (0.263, 0.270)	<2.0×10−16	5.42×10−5

^aUKB, UK Biobank; SD, standard deviation; LDL, low-density lipoprotein; HDL, high-density lipoprotein.

^bP-value was obtained from the interaction term between lipid PGS and fish oil supplementation. Models were adjusted for lipids PGS, fish oil supplementation, sex, age, age², assessment centers, genotyping array, the top 20 genetic principal components, body mass index, Townsend deprivation index, smoking status, alcohol status, physical activity, and statin use.

^cModels were adjusted for sex, age, age², assessment centers, genotyping array, and the top 20 genetic principal components.

^dModels were adjusted for sex, age, age², assessment centers, genotyping array, the top 20 genetic principal components, body mass index, Townsend deprivation index, smoking status, alcohol status, physical activity, and statin use.