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. 2023 Oct 4;12(1):2261248. doi: 10.1080/2162402X.2023.2261248

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Association between LAG-3 expression and clinical outcomes.

a) Representative images (40× magnification) illustrating LAG-3 expression in responders and non-responders. b) Bar graph showing significantly higher percentage of LAG-3+ cells in responders compared to non-responders. c) Bar graph demonstrating no significant differences in the percentage of LAG-3+ cells between responders and non-responders based on site of disease. Kaplan–meier curves comparing d) progression-free survival and e) overall survival between patients with LAG-3-positive and LAG-3-negative tumors using the log-rank (Mantel-Cox) test. Error bars represent median ±95% CI. *P < .05, ns – non-significant, as determined by a Mann–Whitney U test. SQ – subcutaneous, LN – lymph node, R – responder, NR – non-responder.