Table 2.
Univariate and multivariate logistic regression analyses for response to combination anti-LAG-3 + anti-PD-1-based immunotherapy.
| Univariate Analysis |
Multivariate Analysis |
|||||||
|---|---|---|---|---|---|---|---|---|
| OR | Lower CI | Upper CI | P value | Adjusted OR | Lower CI | Upper CI | P value | |
| Baseline LDH | ||||||||
| Elevated | 1 | 1 | ||||||
| Normal | 6.042 | 1.681 | 21.718 | .0059 | 5.581 | 0.984 | 31.665 | .0522 |
| LAG-3 status | ||||||||
| Negative | 1 | 1 | ||||||
| Positive | 5.94 | 1.648 | 21.41 | .0065 | 13.594 | 2.083 | 88.726 | .0064 |
| M stage at entry | ||||||||
| M0/M1a/b | 1 | 1 | ||||||
| M1c/d | 0.097 | 0.019 | 0.492 | .0048 | 0.082 | 0.011 | 0.599 | .0137 |
| TIL score | ||||||||
| High | 1 | 1 | ||||||
| Low | 0.489 | 0.132 | 1.809 | .2836 | 2.29 | 0.347 | 15.101 | .3894 |
Abbreviations: LDH – lactate dehydrogenase; LAG-3 – lymphocyte activation gene-3; TIL – tumor-infiltrating lymphocyte; OR – odds ratio; CI – confidence interval.
Significant P values are in bold.