Manasa 2018.

Study characteristics
Methods	Study design: single‐center parallel‐group RCT Number randomized: Total: 100 eyes of 100 participants PPV with ILM inverted flap: 50 PPV with ILM peeling: 50 Exclusions after randomization: no Losses to follow‐up Total: 9 eyes PPV with ILM inverted flap: 7 PPV with ILM peeling: 2 Unit of analysis: participant (1 eye per participant) Number analyzed Total: 91 eyes PPV with ILM inverted flap: 43 eyes PPV with ILM peeling: 48 eyes Handling of missing data: complete‐case analysis Sample size calculation: NR
Participants	Country: India Mean age Total: 62.18 years PPV with ILM inverted flap: 63.41 years PPV with ILM peeling: 60.95 years Gender PPV with ILM inverted flap: 20/43 (46.5%) men and 23/43 (53.5%) women PPV with ILM peeling: 22/48 (45.8%) men and 26/48(54.2%) women Mean preoperative BCVA in logMAR Total: NR PPV with ILM inverted flap: 0.99 PPV with ILM peeling: 1.1 Mean preoperative MH index in mm Total: NR PPV with ILM inverted flap: 0.339 (SD 0.06) PPV with ILM peeling: 0.34 (SD 0.05) Mean preoperative MH minimum diameter in mm Total: NR PPV with ILM inverted flap: 673 PPV with ILM peeling: 657.5 Mean preoperative MH base diameter in μm (SD) Total: NR PPV with ILM inverted flap: NR PPV with ILM peeling: NR Pseudophakia status PPV with ILM inverted flap: NR PPV with ILM peeling: NR Inclusion criteria Idiopathic FTMH with minimum linear diameter ≥ 600 μm Exclusion criteria Traumatic MH Associated ocular conditions (e.g. diabetic retinopathy, age‐related macular degeneration, high myopia, retinal detachment, glaucoma) Types of MH in the study: idiopathic Equivalence of baseline characteristics: yes: age, duration, preoperative visual acuity, minimum linear diameter, and MH index were comparable between groups.
Interventions	Intervention: PPV with ILM inverted flap (type of inverted flap technique: the ILM flap was inverted and placed over the hole with a soft‐tipped cannula or a diamond‐dusted membrane scraper) Control: PPV with ILM peeling Cointerventions: NR Follow‐up Planned: 1 week, 1 month, 3 months Actual: 1 week, 1 month, 3 months Type of tamponade: 20% SF6 with air was left in the vitreous cavity. Postoperatively, face‐down positioning was prescribed for 3 days. Number of surgeons performing surgeries: NR
Outcomes	Primary outcomes BCVA ("BCVA was measured using the standard ETDRS chart and converted to logMAR for statistical analysis.") Postoperative MH closure Secondary outcomes mfERG Safety outcomes: no postoperative complications or adverse events were reported. Time points of measurement: 1 week, 1 month, 3 months
Notes	Publication type: published article Funding sources: none reported Disclosures of interest: "The authors declare that they have no competing interests." Trial registry: none reported Study period: NR Subgroup analyses: no Publication language: English