Michalewska 2010.

Study characteristics
Methods	Study design: single‐center parallel‐group RCT Number randomized Total: 101 eyes of 86 participants PPV with ILM inverted flap: 50 eyes of 46 participants PPV with ILM peeling: 51 eyes of 40 participants Exclusions after randomization: no Losses to follow‐up: none reported Unit of analysis: eye Number analyzed Total: 101 eyes of 86 participants PPV with ILM inverted flap: 50 eyes of 46 participants PPV with ILM peeling: 51 eyes of 40 participants Handling of missing data: NR Sample size calculation: NR
Participants	Country: Poland Mean age Total: 65.5 years PPV with ILM inverted flap: 66 years PPV with ILM peeling: 65 years Gender PPV with ILM inverted flap: 13/50 (28%) men and 33/50 (72%) women PPV with ILM peeling: 8/51 (20%) men and 32/51 (80%) women Mean preoperative BCVA in logMAR Total: NR PPV with ILM inverted flap: 1.1 PPV with ILM peeling: 0.92 Mean preoperative MH index in mm Total: NR PPV with ILM inverted flap: NR PPV with ILM peeling: NR Mean preoperative MH minimum diameter in mm Total: NR PPV with ILM inverted flap: 759 (range 415 to 1618) PPV with ILM peeling: 698 (range 405 to 1126) Mean preoperative MH base diameter in μm Total: NR PPV with ILM inverted flap: NR PPV with ILM peeling: NR Pseudophakia status PPV with ILM inverted flap: 2/50 (4%) PPV with ILM peeling: 4/51 (10%) Inclusion criteria Idiopathic FTMH with minimum diameter > 400 μm Exclusion criteria Severe retinal pathology (e.g. proliferative diabetic retinopathy, exudative age‐related macular degeneration, retinal detachment) Types of MH in the study: idiopathic Equivalence of baseline characteristics: yes: sex, age, minimum diameter, base diameter, and visual acuity were comparable between groups.
Interventions	Intervention: PPV with ILM inverted flap (type of inverted flap technique: manipulated over the hole) Control: PPV with ILM peeling Cointerventions: "Cataract surgery in 9 patients (6 in group 1 and 3 in group 2) was performed during the time of this study (4–11 months after surgery)." Follow‐up Planned: 1 week, 1 month, 3 months, 6 months, 12 months Actual: 1 week, 1 month, 3 months, 6 months, 12 months Type of tamponade: air Number of surgeons performing surgeries: 1
Outcomes	Primary outcomes Visual acuity (measured as mean BCVA using Snellen tables) Postoperative MH closure Secondary outcomes: not specified Safety outcomes: no postoperative complications or adverse events were reported. Time points of measurement: 1 week, 1 month, 3 months, 6 months, 12 months
Notes	Publication type: published article Funding sources: none reported Disclosures of interest: "The author(s) have no proprietary or commercial interest in any materials discussed in this article." Trial registry: none reported Study period: NR Subgroup analyses: no Publication language: English