CTRI/2017/03/008001.

Study name	Comparison between standard surgical technique versus newer technique for large holes in the centre of the retina: a prospective randomised control trial
Methods	Study design: single‐center parallel‐group RCT Number randomized: 102 in total Exclusions after randomization: none reported Unit of analysis: NR Handling of missing data: NR
Participants	Country: India Inclusion criteria Age 40–80 years Idiopathic MH or MH secondary to other etiology MH size > 500 μm Exclusion criteria Previously failed MH surgery MH size < 500 μm Requirement for both IOL and MH surgery Baseline OCT scan with signal strength < 5 Other ocular comorbidities that can affect final visual outcome Monocular vision Types of MH in the study: idiopathic
Interventions	Intervention: PPV with ILM inverted flap (type of inverted flap technique: NR) Control: PPV with ILM peeling Planned follow‐up: 12 months Type of tamponade: SF6
Outcomes	Primary outcomes MH closure Secondary outcomes Distance BCVA Time points of outcome measurement: 12 months
Starting date	3 September 2017
Contact information	Prabu Baskaran, Aravind Eye Hospital. Email: prabubaskaran@gmail.com
Notes	Sponsorship source: Aravind Eye Hospital, Cuddalore Main Road, Thavalakuppam, Pondicherry 605007, India