NCT04698226.

Study name
Methods	Study design: single‐center parallel‐group RCT Number randomized: 60 in total Exclusions after randomization: none reported Unit of analysis: NR Handling of missing data: NR
Participants	Country: Czechia Inclusion criteria Age > 18 years Idiopathic FTMH verified on OCT (Gass stage 2–4) Minimal MH size < 1000 um Pseudophakia Exclusion criteria Presence of other ocular pathology influencing visual acuity (e.g. age‐related macular degeneration, diabetic retinopathy) Unwillingness to sign the informed consent form Inability to attend study visits Health status not allowing participation in the study Types of MH in the study: Idiopathic
Interventions	Intervention: PPV with ILM inverted flap (type of inverted flap technique: "Flower petal" type) Control: PPV with ILM peeling Planned follow‐up: 6 months Type of tamponade: SF6
Outcomes	Primary outcomes Near BCVA on Salzburg reading desk Microperimetry – macular integrity Microperimetry – average threshold Microperimetry – fixation stability MH closure rate Secondary outcomes Distance BCVA Occurrence of perioperative complications at month 3 (e.g. retinal breaks) Occurrence of postoperative complications at month 6 (e.g. intraocular hemorrhage, retinal detachment) Time points of outcome measurement: 3 months (perioperative complications), 6 months
Starting date	NR
Contact information	Martin Pencak. Faculty Hospital Kralovske Vinohrady. Email: pencak@volny.cz
Notes	Sponsorship source: Faculty Hospital Kralovske Vinohrady

BCVA: best‐corrected visual acuity; ERG: electroretinogram; FTMH: full‐thickness macular hole; ILM: internal limiting membrane; IOL: intraocular lens; MH: macular hole; NR: not reported; OCT: optical coherence tomography; PPV: pars plana vitrectomy; RCT: randomized controlled trial; SD: standard deviation; SD‐OCT: spectral domain optical coherence tomography.