Fig 3. Determinants of post-treatment rebound setpoint viral load.

We analysed animals from the three cohorts to understand factors associated with the post-rebound setpoint viral level. Viral load at treatment (A) and peak viral load before treatment (B) where poorly predictive of post-rebound setpoint viral load when data from all treatment times was combined. However, when we divided the animals into those treated before day 20 and after day 20, clear patterns emerged. (C,D) For animals treated before day 20, the viral load at treatment (C) does not predict setpoint viral load at rebound. Instead, the day of treatment (D) is a significant predictor of the setpoint viral load. (E,F). In animals treated after 20 days post-infection, viral load at treatment is a good predictor of the rebound setpoint viral load (E), while the rebound peak viral load is only weakly associated with rebound setpoint (F).