Fig 7. Duration of post-rebound viral control to <10,000 copies/ml.

In order to compare the duration of post-rebound control, we compared the proportion of each cohort that maintained post-rebound viral loads below 10,000 copies per ml at different times after ATI. The first 30 days after detection of viral rebound are ignored to avoid the initial post-rebound peak of viral load in the analysis of the duration of viral control (shaded grey). A. The proportion of animals maintaining viral control over time post-rebound is higher in groups treated around the optimal time, however the difference is not significant when comparing three groups together (p-values for the log-rank test are shown in the figures). Coloured stars indicate groups where all animals had viral loads greater than 10,000 copies per ml at day 30 post detection. B. Animals that have a low peak of the virus during early rebound are more likely to maintain low viral control over time. C. Having a low viral growth rate during post-treatment rebound is also associated with longer-term control of post-rebound viral loads.