Summary of findings 3. Regular‐dose postoperative 5‐Fluorouracil versus control for glaucoma surgery ‐ combined surgery subgroup.
| Regular‐dose postoperative 5‐FU versus control for glaucoma surgery | ||||||
| Patient or population: participants with glaucoma surgery Settings: ophthalmic surgery Intervention: regular‐dose postoperative 5‐FU versus control | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | Regular‐dose postoperative 5‐FU versus control | |||||
| Failure at 12 months ‐ combined surgery | See comment | See comment | Not estimable | 118 (2 studies) | ⊕⊝⊝⊝ very low1,2 | No surgical failures reported in either 5‐FU or control group. |
| Mean intraocular pressure at 12 months ‐ combined surgery | The mean intraocular pressure at 12 months ‐ combined surgery in the control groups was 16.19 mm Hg | The mean intraocular pressure at 12 months ‐ combined surgery in the intervention groups was 1.02 lower (2.4 lower to 0.37 higher) | ‐ | 118 (2 studies) | ⊕⊕⊝⊝ low1 | ‐ |
| Complications ‐ wound leak ‐ combined surgery Follow‐up: 12 months | 143 per 1000 | 129 per 1000 (51 to 319) | RR 0.9 (0.36 to 2.23) | 118 (2 studies) | ⊕⊕⊝⊝ low1 | ‐ |
| Complications ‐ hypotonous maculopathy ‐ combined surgery ‐ not reported | See comment | See comment | Not estimable | ‐ | See comment | Outcome not reported. |
| Complications ‐ shallow anterior chamber ‐ combined surgery Follow‐up: 12 months | See comment | See comment | Not estimable | 118 (2 studies) | ⊕⊝⊝⊝ very low1,2 | Shallow anterior chamber was not reported to occur in either 5‐FU or control group. |
| Complications ‐ epithelial toxicity ‐ combined surgery Follow‐up: 12 months | 125 per 1000 | 380 per 1000 (195 to 740) | RR 3.04 (1.56 to 5.92) | 118 (2 studies) | ⊕⊕⊝⊝ low1 | ‐ |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). 5‐FU: 5‐Fluorouracil; CI: confidence interval; RR: risk ratio. | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 The quality of this evidence is reduced by the risk of performance and detection bias in both O'Grady 1993 and Wong 1994. 2 As no events were recorded, no effect can be estimated.