Fig. 4. The HSC lentiviral integrome signatures are present in lentiviral-transduced T cells.
(A) Correlation coefficients for the density profiles of integration sites across all CD19-CAR T cell samples and four patients with SCID-X1. (B) Top RIGs in CD19-CAR T cell samples. The list comprises RIGs identified in SCID-X1 (red), as shown in Fig. 1D, and RIGs specific for CD19-CAR T cells (green). SCID-X1 and CD19-CAR T cell RIGs are partially shared.