Table 3.

Characteristics of patients based on genetic test outcomes.

	Subjects with positive genetic test (n = 5)	Subjects with negative genetic test (n = 35)	P-value
Age at diagnosis (years)	54.2 ± 16	50.8 ± 15	0.6526
Calcium (mmol/L)	3.36 ± 0.49	2.99 ± 0.49	0.0817
PTH (pmol/L)	134.95 ± 159.25	38.18 ± 48.65	0.1582
Mean P min pre-surgery (mmol/L)	0.63 ± 0.19	0.87 ± 0.4	0.1005
Calcium creatinine clearance ratio (CCCR)*	0.0085	0.022	0.0057
More than one inclusion criteria (%)	3/5 (60 %)	10/35 (28.6 %)	0.1605

Data are expressed as mean ± standard deviation. The positive genetic test group included patients with LP or P variants, according to the ACMG criteria. The negative genetic test group included subjects with VUS variants or those without any variants found in the genes studied. *CCCR was analysed with Wilcoxon test being lower in subjects with class LP or P variants when compared to subjects with negative genetic test (P = 0.005). When analysing the differences in CCCR between patients who presented with each type of mutation (CASR, CDKN1B, or non-mutated; Kruskal-Wallis test), a statistically significant difference was observed (P = 0.02), mainly at the expense of subjects with mutated CASR, in whom the CCCR value was much lower.