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NLRP3 signaling pathway and targets of inhibitors against neuroinflammation in AD. NLRP3, NOD-like receptor thermal protein domain associated protein 3; AD, Alzheimer's disease; 1, dapansutrile; 2, JC124; 3, MCC950; 4, ginkgolide B; 5, paeoniflorin; 6, A419259; 7, TAK-242; 8, CLI-095; 9, PEG-PEI/short interfering ROCK2; 10, pterostilbene; 11, LDS; 12, sulfa-4 and sulfa-22; Aβ, amyloid β; LPS, lipopolysaccharide; TLRs, Toll-like receptors; MyD88, myeloid differentiation factor 88.
