TABLE 3.
Therapeutic efficacy of topically applied NND-502, lanoconazole, and terbinafine in the guinea pig model of tinea pedis (second experiment)d
| Treatment | No. of culture-positive feet/total no. of feet (%) | Average intensity of infection score |
|---|---|---|
| Control | ||
| Untreated | 10/10 (100) | 8.2 |
| PEG400a | 10/10 (100) | 8.15 |
| NND-502 (%) | ||
| 0.25 | 7/10 (70) | 0.7b,c |
| 0.5 | 2/10 (20)b,c | 0.1b,c |
| 1 | 0/10 (0)b,c | 0b,c |
| Lanoconazole (%) | ||
| 0.25 | 9/10 (100) | 1.65 |
| 0.5 | 6/10 (60)b,c | 0.95b,c |
| 1 | 3/10 (30)b,c | 0.25b,c |
| Terbinafine (%) | ||
| 0.25 | 9/10 (90) | 1.4 |
| 0.5 | 5/10 (50)b,c | 0.45b,c |
| 1 | 3/10 (30)b,c | 0.25b,c |
a
Polyethylene glycol 400.
b
Significantly different (P < 0.05) from values obtained for the untreated control group.
c
Significantly different from values obtained for the PEG400 group.
d
No significant differences were found in any of the parameters among the comparable NND-502, lanoconazole, and terbinafine groups.