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. 2023 Oct 6;13:16839. doi: 10.1038/s41598-023-44174-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MALAT1 expression is an independent prognostic factor for time to treatment (TTT) in CLL. (a) CLL patients with high MALAT1 expression showed significantly shorter TTT compared to those with low levels in the global cohort (top panel) and almost every one of the different CLL subgroups related to the IGHV mutational status (bottom left) and epigenetic subtypes (bottom right). (b) Plot for multivariate model analyses, where MALAT1 expression as a continuous variable shows its independent prognostic value considered together with Binet stage and IGHV mutational status (left panel) or epigenetic subtypes (right panel). For epigenetic groups, m-CLL was taken as a reference.