Table 1.
Different HBOCs sources, solvents and particle size.
| Polyhemoglobin | Source | various of buffers | Mean diameter | Ref. |
|---|---|---|---|---|
| Hb-MPs | BHb | EDTA solution (0.2 M, pH 7.4, 20 mL) | 3.30 ± 0.80 μm | [10] |
| ZnPc-loaded HbMs | BHb | Phosphate buffer (10 mM, pH = 7.4) | 66.01 ± 0.95 nm | [11] |
| PLGAHb/M-NCs | BHb | Tris(hydroXymethyl) aminomethane (TRIS) | ～95 nm | [[12], [13]] |
| PDA-Hb | BHb | Tris-HCl buffer (10 mM, pH 8.5) | 3.32 ± 0.49 μm | [14,15] |
| Hb@lipo | HHb | pH 7.4 PBS | ～120 nm | [16] |
| BP QDs-Hb-encapsulated biocompatible | HHb | Deionized water | NA | [17] |
| GelMA hydrogel | ||||
| Hb-PDA | BHb | Tris-HCl buffer (10 mM, pH 8.5) | 6–8 nm | [18] |
| Hb-conjugated biotins | HHb | Phosphate buffer (50 mM, pH 6.5) | NA | [19] |
| SA@Hb@CQDs | HHb | Deionized water | NA | [20] |
| ZIF-8P-Hb | BHb | Deionized water | 106.0 ± 9.7 nm | [21] |
| SFHbNP | HHb | Phosphate buffer (10 mM, pH 7.4) | ～90 nm | [22] |
| HbAvHb | HHb | Phosphate buffer (50 mM, pH 6.5) | NA | [23] |
| SPolyHb | Guinea pig hemoglobin | Phosphate buffer (50 mM, pH 7.4) | ＞500 kDa | [24] |
| Hb@lipo | HHb | phosphate-buffered (pH 7.4) | ～120 nm | [25] |
| HEP | BHb | phosphate-buffered (pH 7.4) | ～200 nm | [26] |
| Hb-PEG | HHb | Phosphate buffered (10 mM Na2HPO4, pH 7.4) | 10.6 ± 3.6 nm | [27] |
| PolyhHbs | BHb | Phosphate buffered (10 mM, pH 7.4) | ～80 nm | [28] |
| Hb-V | HHb | Phosphate buffered (10 mM, pH 7.4) | 250–280 nm | [29] |
| Fe3O4-PEI-PA-Yb3+ | BHb | Tris-HCl (pH 6) | ～105 nm | [30] |