Table 2.
Univariate and multivariate analyses of clinicopathological characteristics and Methylation risk score with RFS in the entire TCGA-LIHC dataset.
| Variables | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Methylation risk score (High/Low) | 3.47(2.49–4.83) | 1.824e-13* | 3.70 (2.57–5.34) | <0.001* |
| Vascular invasion (Yes/No) | 1.41(1.03–1.93) | 0.035* | 1.52(1.01–2.28) | 0.046 |
| Adjacent tissue inflammation (Yes/No) | 1.32(0.95–1.83) | 0.010 | ||
| Age (>60/≤60 years) | 0.97(0.73–1.28) | 0.813 | ||
| Albumin (≥4.0/<4.0 g/dl) | 0.79(0.59–1.06) | 0.112 | ||
| Creatinine (≥1.1/<1.1 mg/dl) | 0.83(0.61–1.13) | 0.239 | ||
| AFP (>20/≤20 ng/ml) | 0.98(0.72–1.33) | 0.881 | ||
| Liver cirrhosis (Yes/No) | 1.38(1.00–1.93) | 0.054 | ||
| Histological grade (G3-4/G1-2) | 1.06(0.80–1.41) | 0.689 | ||
| Platelet (≥200/<200 × 109/L) | 1.03(0.77–1.38) | 0.834 | ||
| Family history (Yes/No) | 0.93(0.67–1.29) | 0.667 | ||
| Gender (male/female) | 1.09(0.8–1.485) | 0.584 | ||
| Race (Asian/not Asian) | 1.04(0.79–1.39) | 0.765 | ||
| TNM stage (II/I) | 1.40(1.05–1.87) | 0.023* | 0.96(0.64–1.43) | 0.836 |
| BMI (≥25/<25 kg/m2) | 0.95(0.71–1.27) | 0.712 | ||
| HBV (Yes/No) | 0.88(0.65–1.20) | 0.416 | ||
| Alcohol consumption (Yes/No) | 0.83 (0.53–1.30) | 0.421 | ||
Abbreviations: RFS, recurrence-free survival; HR, hazard ratio; 95% CI, 95% confidence interval.
*Statistically significant; AFP, Alpha-fetoprotein; BMI, body mass index.