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. 2023 Oct 6;14(10):652. doi: 10.1038/s41419-023-06171-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A γ-H2AX expression across various treatments were determined by immunofluorescence. B The expression of p-Nfr2 (S40) across different treatments were determined by immunofluorescence. C γ-H2AX level across various treatments was quantitatively analyzed, and γ-H2AX expression were detected by immunoblotting. D The p-Nfr2 (S40) expression across different groups was quantitatively analyzed. E NADPH level in cells treated with PI3K/mTOR inhibitors combined with or without IR was detected. F, G ROS level of H446RR cells across different groups was detected using MitoSOX Red, and the mean level of ROS were obtained.