Skip to main content
. 2023 Oct 6;14(10):652. doi: 10.1038/s41419-023-06171-7

Fig. 6. Whether PI3K/AKT/mTOR signaling, ROS and G6PD contributed to SCLC radioresistance were validated.

Fig. 6

A The correlation between oxidative stress-related genes, including G6PD, CAT, HMOX1, NFE2L2 and NQO1, and overall survival (OS) among SCLC patients. B The specific cell death of SBC2 and H446RR cells treated with IR plus insulin were determined by CCK8 assay. C The specific cell death of SBC2 and H446RR cells treated with PI3K/mTOR inhibitors, IR and NAC were determined by CCK8 assay. D The cell growth of SBC2 cells treated with PI3K/mTOR inhibitors, IR and NAC were determined by clone formation assay. E The specific cell death of SBC2 and H446RR cells treated with PI3K/mTOR inhibitors, IR and 6-AN were determined by CCK8 assay. F The cell growth of SBC2 cells treated with PI3K/mTOR inhibitors, IR and NAC were determined by clone formation assay. G The cell proliferation ability cells in mock-vehicle groups or cells transfected with G6PD overexpression vector were detected by CCK8 assay.