Table 4.

Summary of size heterogeneity and aggregate profile assessed by SEC-MALS in thermal and mechanical stress conditions. (n = 3).

Parameter evaluated	Molar mass moments (gm mol−1)
	HMW			Intact mAb
Bvz Brands	Avt	Bio-1	Bio-2	Avt	Bio-1	Bio-2
Control	nda	nd	nd	1.497 × 105 (±2.598%)	1.473 × 105 (±2.356%)	1.464 × 105 (±2.127%)
50 °C, 1 d	nd	nd	nd	1.498 × 105 (±2.678%)	1.474 × 105 (±2.387%)	1.466 × 105 (±2.237%)
50 °C, 7 d	4.424 × 105 (±3.855%)	4.570 × 105 (±4.163%)	4.724 × 105 (±3.855%)	1.464 × 105 (±2.066%)	1.473 × 105 (±2.045%)	1.495 × 105 (±2.855%)
50 °C, 14 d	9.484 × 105 (±2.490%)	9.313 × 105 (±2.405%)	9.853 × 105 (±2.450%)	1.495 × 105 (±2.373%)	1.507 × 105 (±2.166%)	1.528 × 105 (±2.449%)
200 rpm, 1 h	nd	nd	nd	1.497 × 105 (±2.578%)	1.473 × 105 (±2.436%)	1.464 × 105 (±2.747%)
200 rpm, 12 h	2.952 × 105 (±2.807%)	2.832 × 105 (±2.627%)	2.982 × 105 (±2.627%)	1.465 × 105 (±2.160%)	1.479 × 105 (±2.531%)	1.485 × 105 (±1.936%)
200 rpm, 24 h	7.415 × 105 (±2.309%)	7.107 × 105 (±2.419%)	7.726 × 105 (±2.229%)	1.445 × 105 (±1.790%)	1.465 × 105 (±2.443%)	1.461 × 105 (±2.720%)

^and; not detected.