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Morphological and cytological changes in the spleen after the treatment of recombinant proteins. A) Splenomegaly observed after the treatment of 30Kc19α‐RUNX2 and HAB‐30Kc19α‐RUNX2. Following 4 weeks of protein injection, spleens were dissected to evaluate protein delivery to the spleen and the immune response induced by external protein injection. Scale bar: 10 mm B) H&E staining showing the cellular and histomorphological change in the spleen.
