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. 2023 Aug 16;10(28):2206692. doi: 10.1002/advs.202206692

Figure 1.

Figure 1

Treg‐specific BATF deletion results in homeostatic dysregulation with multiorgan autoimmune pathology. A) Body weight at 8 weeks of age of Treg‐specific BATF KO (Foxp3 Cre Batf F/F) mice and control mice (Foxp3 Cre Batf +/+). B) Survival curve of Foxp3 Cre Batf F/F (n = 15, red line) compared to Foxp3 Cre Batf +/+ (n = 14, black line). C) Representative images showing development of splenomegaly, lymphadenopathy, and shorter, inflamed colons in Foxp3 Cre Batf F/F mice compared to control mice around 8–10 weeks of age. D) H&E staining of tissue sections from lung, liver, and colon from Foxp3 Cre Batf F/F mice compared to control mice (20× magnification). E,F) Frequency of activated E) CD4 and F) CD8 T cells in different tissues in Foxp3 Cre Batf F/F mice compared to control around 8–10 weeks of age. S‐LPL, small intestine lamina propria. L‐LPL, large intestine lamina propria. All data are pooled from at least three individual repeats with a minimum of 3–5 mice per group. Data here are shown ± SEM. *p < 0.05, ** p < 0.01, and *** p < 0.001 (two tailed unpaired t‐test).