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. 2023 Aug 23;10(28):2302519. doi: 10.1002/advs.202302519

Figure 7.

Figure 7

Verification of interaction mechanism between HASPy and Schwann cells. A) Gene expression of CD44, IL‐17 and IL‐17RA in TCP, HA and HASPy (*p < 0.05, **p < 0.01, n = 3). B) The cytokine secretion of IL‐17 in the supernatant of Schwann cells was detected by ELISA (*p < 0.05, **p < 0.01, n = 3). C) Immunofluorescence of Schwann cells in TCP, HA, and HASPy groups before and after inhibitor (up: IL‐17RA; down: +Ixekizumab IL‐17RA). Scale bar: 250 µm. D) Fluorescence intensity of IL‐17RA (*p < 0.05, **p < 0.01, n = 3). E) Gene expression of IL‐17RA, CD44, and S100‐β in Schwann cells cultured on HA and HASPy hydrogel with Ixekizumab (*p < 0.05, **p < 0.01, n = 3). F) Mechanism summary of HASPy on Schwann cells' behavior.