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. 2023 Aug 16;10(28):2207518. doi: 10.1002/advs.202207518

Figure 1.

Figure 1

Systemic inflammatory response, impaired cellular immunity, and circulating tumor cells were detected after osteosarcoma surgeries. A) clinical images from a 13‐year‐old male with osteosarcoma in the distal femur, receiving amputation surgery, and a 14‐year‐old female in the distal femur, receiving limb‐salvage surgery. B) Statistics of circulating monocytes and neutrophil/lymphocytes ratio before and after osteosarcoma surgeries. Data are presented as means ± SEM (Student's t‐test; n = 19 to 20). C) Comparison of C‐reactive protein, pro‐inflammatory cytokine IL‐6, and IL‐8 before and after surgeries. Data are presented as means ± SEM (Student's t‐test; n = 5 to 11). D) Statistics of the CD3+CD4+ T cells and CD3+CD8+ T cells before and after osteosarcoma surgeries. Data are presented as means ± SEM (Student's t‐test; n = 9 to 11). E) fluorogram reflecting circulating tumor cells in case 1 before surgery (Green fluorogram representing tumor cells with mesenchymal origination). F) Clinical information of included patients with osteosarcoma for circulating tumor cells evaluation before and after surgeries.