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. 2023 Aug 1;10(28):2301645. doi: 10.1002/advs.202301645

Figure 2.

Figure 2

Adipocyte‐specific deletion of Mettl14 protects against diet‐induced obesity. Male and female mice (8 weeks) were fed a high fat diet (HFD) for 10 weeks. A) Grown curves. Male Mettl14f/f: n = 9, male Mettl14Δfat: n = 12, female Mettl14f/f: n = 6, female Mettl14Δfat: n = 10. B) Fat content and lean mass were measured by pDexa (HFD for 10 weeks). Male Mettl14f/f: n = 6, male Mettl14Δfat: n = 9, female Mettl14f/f: n = 5, female Mettl14Δfat: n = 7. C) White adipose tissue (WAT) weights on HFD for 16 weeks. Male Mettl14f/f: n = 9, male Mettl14Δfat: n = 12, female Mettl14f/f: n = 6, female Mettl14Δfat: n = 10. D–G) Mice (7 weeks) were injected with tamoxifen and fed a HFD. D) Growth curves. f/f‐Tam: n = 6, Δfat‐Tam: n = 5. E) Fat content and lean mass on HFD for 10 weeks. f/f‐Tam: n = 6, Δfat‐Tam: n = 5. F,G) WAT weights on HFD for 10 weeks. Male Mettl14f/f: n = 6, male Mettl14Δfat: n = 5, female Mettl14f/f: n = 3, female Mettl14Δfat: n = 5. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, Student's t test (B,C,E–G) and ANOVA (A,D).