Table 3.
Case of malign over ca releasing cortisole published in the literature, includıng current case.
| Case | Age | Clinical table | Laboratory results | Acth | Imaging | Operation | Pathology | Prognosis |
|---|---|---|---|---|---|---|---|---|
| (Marieb et al., 1983)(9) | 35 | - Cushing syndrome - Severe Virilization - Peripheral edema - Amenorrhea - Lower Abdominal mass - BP = 150/80 mmHg | -Ürinary and plasma cortisole- Urinary 17-hydroxysteroids and 17-ketosteroids- higher than plasma levels Low FSH and LH | Low = 28 pg / mL (20–100) | Bilateral ovarian mass. No adrenal mass, adrenals are of normal size | Bilateral ovarian mass Omentum cul-de-sac and mesentery implants Normal adrenals |
Right ovarian Carcinoma = 15 cm Left one = 8 cm Widespread metastasis Classification: Ovarian Tumour of malignant steroid cells | Normalization of steroids followed by recurrent chemotherapy failure, exitus after 17 months |
| Young et al(1987) (10) | 48 | - Cushing syndrome - Light virilization - BP: 180/110 mmHg - Diabetes mellitus | Increased cortisole | – | Right Adnexial Mass | Yellow brown colored ovary. Yellow brown nodules on visceral and parietal peritoneum. Omentum and diaphragma normal | steroid cell (lipid cells) type abdominal metastesesı | Normalization of steroids and blood pressure. Recurrence on month 3 chemotherapy failure, exitus on month 10 |
| Donovan vd.(1993) (11) | 66 | Abdominal-pelvic mass - Lower extremity edema - Diabetes mellitus Cushing syndrome + Post operational Hipertension |
Hipokalemia increased - CA125 - Plasma and urine cortisol - DHEA - S - Testosteron - Androstenedione | Normal | – | The small intestine has several attached loops 8 cm multiloculated right ovarian tumor |
Ovarian Tumors of malignant steroid cells Metastases: colon and intestines, omentum and liver |
Ketoconazole and classic chemotherapy failure, exitus in 4 months |
| Young and Scully vd(1987)(10) | 52 | - Cushing syndrome - Hirsutism - High Blood pressure for 17 years(170/100) - Diabetes mellitus | Increased Ürinary and plasma cortisol- Urinary 17-hydroxysteroids and 17-ketosteroids- | Normal | Noırmal venographic imaging of adrenals | Right ovarian tumor,Widespread metastases to omentum |
Malignant ovarian tumor with an intact capsule 135 gr (9 × 7 × 5 cm) Malignant looking omental lesions | Exitus in 6 months |
| Elhadd vd.(1996) (12) | 73 | Rapidly progressing Cushing syndrome - Virilisation (clitoromegali + severe hirsutism) - Hipertension 220/120 mmHg | Increased Ürinary and plasma cortisol- Urinary Free cortisol-Testosterone - Estradiol − 17-OHP Low: FSH ve LH |
Low < 10 pg / mL | No Adrenal Mass No ovarian mass Venous catheter shows left ovarian origin | Left ovarian mass Atrophic right ovary | 2 × 2 × 1 cm lipit hücreli tümör, ancak kesin malignite kanıtı yok | No adjuvant treatment - Recurrence after 12 months peritoneal and omental metastases |
| Farida vd(2016) (17) |
34 | Cushing syndrome - Psychiatric problems - Hirsutism - Hypertension - Diabetes mellitus - Lower extremity edema - Pelvic Mass | High: - Cortisol - Estradiol - Testosterone − 17-OHP | Low < 10 pg / mL | No Adrenal Mass Small adrenals Ovarian tumor | - Ovarian tumor: -Hemoperitoneum - Lymph nodes | - Ovarian tumor 14 × 13 cm- Peritoneum and lymph node metastases | No adjuvant treatment, death post op day two due to pulmonary embolism |
| 2019 Case |
21 | Cushing syndrome - Psychiatric problems - Hirsutism – paraplegia- diabetes mellitus - pelvic mass | High: - Plasma and free urine cortisol- | HighACTH (89 pg/m l) |
Bilateral ovarian mass, No Adrenal Mass Normal adrenals | bilateral adneksıyel kitle batın içi ek patoloji yok | 11x6x5 cm and 9x8x5 cm sized SCLT of ovaries left and right respectively |
Normalization of steroids - Metastasis to the brain on month 3, Radiotherapy and chemotherapy ongoing |