Table 2.

Summary of Monosodium glutamate-induced Metabolic Disorders in Non Mamalian Organisms

Dose and Route of Administration	Duration of Administration	Subject	Result/ Findings	Authors
5 %, 1 %, 0.2 %, 0.04 %	30 Days	Drosophila melanogaster	MSG at dosages on hydrogen peroxide scavenging, negative geotaxis and lifespan in W1118 male D. melanogaster caused no alterations but higher than 5 % MSG on catalase activity, showing alterations to tissue health.	[16]
0.01 mM, 0.05 mM, 0.1 mM, 1 mM, 5 mM, 10 mM, 20 mM and 24 mM	Until larvea dies	Caenorhabditis elegans	MSG exerts a significant reduction of C. elegans lifespan probably via daf-2 gene, implying an effect of insulin signaling pathway on lifespan.	[89]
10, 30, 50, 100, 150, 200, 250, 300, 400, 500 mg/L	4 Days	zebrafish (Danio rerio)	increase of the MSG concentrations led to different observable deformities in zebrafish embryo	[90]