TABLE 1.
Baseline demographic covariates used across the different simulation scenarios for the evaluation of the pharmacokinetics of gabapentin and tramadol in children from 3 months to <18 years of age.
| Children 5–15 kg (n = 400) | Children >15 kg (n = 400) | All children (n = 800) | |
|---|---|---|---|
| Age (years) | 2.0 (0.25–5) | 8.0 (2–17) | 4.0 (0.25–18) |
| Weight (kg) | 12.7 (4.5–15) | 25.7 (15.1–76.6) | 15.1 (4.5–6.6) |
| Height (cm) | 89.3 (58.8–106) | 128.4 (92–181.3) | 100.3 (58.8–181.3) |
| BMI (kg/m2) | 15.8 (12.3–19) | 16.2 (12.7–24.9) | 16 (12.3–24.9) |
| BSA (m2) | 0.55 (0.27–0.66) | 0.98 (0.6–2) | 0.64 (0.27–2) |
| CrCL (mL/min) | 188.3 (79.4–281.5) | 163.2 (92.4–276) | 173.7 (79.4–281.5) |
Note: Values shown are the medians along with the corresponding range.