Table 5. Multivariable-adjusted odds ratios for breast cancer across tertiles of dietary linoleic acid stratified based on menopausal and BMI status .
| Variables | Tertiles of dietary linoleic acid | P -trend * | ||
| Tertile1 | Tertile2 | Tertile3 | ||
| Menopausal status | ||||
| Premenopausal | ||||
| n | 56 | 68 | 75 | |
| Crude | 1 | 0.54 (0.24-1.24) | 0.39 (0.17-0.93) | 0.03 |
| Model 1 | 1 | 0.38 (0.16-0.95) | 0.19 (0.07-0.51) | 0.001 |
| Model 2a | 1 | 0.40 (0.16-1.04) | 0.18 (0.06-0.52) | 0.002 |
| Model 3 | 1 | 0.28 (0.10-0.79) | 0.08 (0.02-0.39) | 0.001 |
| Model 4 | 1 | 0.20 (0.06-0.77) | 0.15 (0.02-0.95) | 0.03 |
| Postmenopausal | ||||
| n | 294 | 282 | 275 | |
| Crude | 1 | 0.38 (0.27-0.53) | 0.43 (0.30-0.60) | < 0.001 |
| Model 1 | 1 | 0.29 (0.20-0.42) | 0.25 (0.17-0.37) | < 0.001 |
| Model 2a | 1 | 0.27 (0.18-0.40) | 0.23 (0.15-0.35) | < 0.001 |
| Model 3 | 1 | 0.38 (0.24-0.60) | 0.67 (0.35-1.29) | 0.07 |
| Model 4 | 1 | 0.42 (0.26-0.68) | 0.77 (0.39-1.53) | 0.19 |
| BMI status | ||||
| Normal weight | ||||
| n | 234 | 206 | 183 | |
| Crude | 1 | 0.48 (0.33-0.70) | 0.40 (0.27-0.60) | < 0.001 |
| Model 1 | 1 | 0.33 (0.22-0.51) | 0.21 (0.13-0.33) | < 0.001 |
| Model 2b | 1 | 0.31 (0.20-0.48) | 0.18 (0.11-0.30) | < 0.001 |
| Model 3 | 1 | 0.37 (0.23-0.62) | 0.29 (0.14-0.63) | < 0.001 |
| Overweight or obese | ||||
| n | 116 | 144 | 167 | |
| Crude | 1 | 0.24 (0.12-0.48) | 0.57 (0.33-0.99) | 0.07 |
| Model 1 | 1 | 0.22 (0.10-0.45) | 0.37 (0.20-0.69) | 0.003 |
| Model 2b | 1 | 0.18 (0.08-0.39) | 0.37 (0.19-0.72) | 0.006 |
| Model 3 | 1 | 0.30 (0.12-0.74) | 2.02 (0.69-5.93) | 0.29 |
Data are presented as OR and 95% CI.
Model 1: Adjusted for age and energy.
a Model 2: Additional adjustment for region, marital status, disease history, physical activity, family history of breast cancer, smoking, alcohol consumption, and socioeconomic status.
b Model 2: Additional adjustment for region, marital status, disease history, physical activity, family history of breast cancer, smoking, alcohol consumption, socioeconomic status and menopausal status.
Model 3: Additional adjustment for intakes of monounsaturated fatty acids, saturated fatty acids, trans-fatty acids, and vitamin E.
Model 4: Additional adjustment for BMI.
Abbreviations: BMI: body mass index; OR: odds ratio; CI: confidence interval.
*Obtained from binary logistic regression