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Mechanistic representation of ATF6-mediated exacerbation of apoptosis in early porcine embryonic development through regulation of organelle homeostasis under HT conditions
HT-induced ER stress in early porcine embryos leads to increased expression of ATF6, followed by its translocation to the Golgi apparatus for cleavage by S1P, thereby inducing AIFM2-mediated apoptosis.
