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. 2023 Sep 6;9(9):e19800. doi: 10.1016/j.heliyon.2023.e19800

Fig. 5.

Fig. 5

Correlation between bacteria-derived DNA (b-DNA) and tumor-infiltrating lymphocytes (TILs) (A) Co-expression pattern of PD-1 and TIM-3 on CD4 T cells of TILs in 88 patients with RCC in Cohort A. CD4 T cells are fractionated into 5 groups (Fr. I: PD-1−TIM-3-, Fr. II: PD-1lowTIM-3-, Fr. III: PD-1highTIM-3-, Fr. IV: PD-1highTIM-3+, Fr. V: PD-1lowTIM-3+). (B) Correlation between the relative abundance of Bacteroidia DNA in serum EVs and PD-1lowTIM-3+CD4 T cells in RCC tissue. (C) Overall survival (OS) and progression-free survival (PFS) after initiation of nivolumab monotherapy for advanced RCC by Bacteroidia DNA in serum EVs. Statistical analysis was performed by log-rank test.