Table 4.
Sensitivity, specificity, positive predictive value and negatif predictive value of PCT, qSOFA, NEWS, NEWS + L and qSOFA + PCT at highest Youden index.
| Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | |
|---|---|---|---|---|
| PCT≥0.38 | 59.35 (50.1–68.1) | 71.05 (59.5–80.9) | 76.84 (69.38–82.93 | 51.92 (45.5–58.28) |
| qSOFA ≥1 | 52.03 (42.8–61.1) | 82.89 (72.5–90.6) | 83.12 (74.47–89.26) | 51.64 (46.38–56.86) |
| NEWS ≥6 | 34.15 (25.8–43.2) | 89.47 (80.3–95.3) | 84 (72.28–91.36) | 45.64 (41.98–49.35) |
| NEWS + L ≥ 4.5 | 69.92 (61–77.9) | 55.26 (43.4–66.7) | 71.67 (65.76–76.91) | 53.16 (44.77–61.39) |
| qSOFA + PCT≥2 | 52.03 (42.8–61.1) | 89.47 (80.3–95.3) | 88.89 (80.26–94.03) | 53.54 (48.56–58.46) |
qSOFA: Quick Sequential Organ Failure Assessment; PCT: Procalcitonin; qSOFA + PCT: Combination of Procalcitonin and qSOFA; NEWS: National Early Warning Score; NEWS + L: Combination of NEWS and Lactate; PPV: Positive Predictive Value; NPV: Negative Predictive Value; CI: Confidence Interval.