Table 2.

Examples of identification of epitopes, antigens, and mimotopes by bio-panning technology, describing the type of vector used (phage or phagemid), the main findings such as screening antibodies, and their therapeutic or prophylactic results.

SOURCE OF ANTIGEN	BACTERIOPHAGE VECTOR	IDENTIFIED ANTIGEN	THERAPEUTIC/PROPHYLACTIC EFFECTS	IDENTIFIED ANTIBODIES	REFERENCE
EGFR GENE	PAK-8 M13 pVIII	EGFR mimotope Triple tandem repeat	Decreased tumor growth Humoral response Lewis lung carcinoma tumor model High level of cytokines Anti-cancer activity	Anti EGFR monoclonal antibody ICR62	[28,28]
MYCOBACTERIUM LEPRAE	M13 (pIII)	Anti M.leprae epitopes	High antibody titer High immunogenicity in mice	Human antiserum	[83,83]
IXODES SCAPULARIS TICKS SALIVARY GLAND	pHORF3 M13	Metalloprotease (MP1)	No evaluated	3 biopanning rounds with human serum antibodies against salivary gland homogenate (SGH)	[84,84]
LEISHMANIA INFANTUM (SYN. L. CHAGASI)	M13	Peptide 5	Protective effect vs. L. infantum in mice model High immunogenicity	Polyclonal IgGs from L. infantum infected dogs	[85,85]
SALMONELLA TYPHIMURIUM	pHORF3 M13	Novel immunogenic antigens	High immunogenicity	Serum from infected pigs	[86,86]
TRICHINELLA SPIRALLIS	M13 (pIII)	Peptide 8F7	High levels of IgG1 Reduction of larvae in vaccinated mice	mAb 8F12	[19,19]