Table 2.
Heart-related biological processes identified from DMR Gene Ontology
| Comparison | GO Term | Genes |
|---|---|---|
| Sex combined | Cardiac muscle contraction | FGF12,PIK3CA,TNNI3 |
| Striated muscle contraction | FGF12,PIK3CA,TNNI3 | |
| Heart contraction | FGF12,PIK3CA,TNNI3 | |
| Heart process | FGF12,PIK3CA,TNNI3 | |
| Ductus arteriosus closure | TFAP2B | |
| Determination of dorsal/ventral asymmetry | NBL1 | |
| Cellular response to erythropoietin | CD40 | |
| Regulation of cardiac conduction | NPR2,TNNI3 | |
| Muscle contraction | FGF12,PIK3CA,TNNI3 | |
| Skeletal muscle contraction | TNNI3 | |
| Females only | Dorsal/ventral pattern formation | FOXG1,GLI2,GREM2,INTU,MDFI,SMAD6,SUFU,TCTN1 |
| Negative regulation of relaxation of cardiac muscle | PDE4D | |
| Negative regulation of heart contraction | AGTR2,PDE4D | |
| Adrenergic receptor signaling pathway involved in heart process | PDE4D | |
| Regulation of heart rate by chemical signal | PDE4D | |
| Regulation of relaxation of cardiac muscle | PDE4D | |
| Aorta development | SMAD6,SUFU,TFAP2B,TGFB2 | |
| Regulation of ventricular cardiac muscle cell membrane repolarization | ANK2,WDR1 | |
| Males only | Septum primum development | ACVR1,GATA4,GJA5,SOX4,TGFB2 |
| Atrial septum primum morphogenesis | ACVR1,GATA4,SOX4,TGFB2 | |
| Atrioventricular canal development | CHD7,FOXN4,HAS2,PTPN11 | |
| Adult heart development | ADRA1A,CHD7,HAND2,SCUBE1,TCAP | |
| Artery smooth muscle contraction | AGT,EDN1,EDN2,HTR2A,MKKS | |
| Right ventricular compact myocardium morphogenesis | CHD7 | |
| Atrial septum secundum morphogenesis | GATA4 | |
| Positive regulation of heart rate | ADRA1A,ADRB1,EDN1,EDN2,EDN3,KCNQ1,PDE4D,RYR2,SCN3B,TACR3,UTS2 | |
| Cardiac muscle hypertrophy | AGT,GATA4,GATA6,HDAC4,KDM4A,LEP,PPP3CA,RYR2,TCAP,TIAM1,TTN | |
| Positive regulation of heart contraction | ADRA1A,ADRB1,EDN1,EDN2,EDN3,KCNQ1,PDE4D,RGS2,RYR2,SCN3B,TACR3,TGFB2,UTS2 | |
| Septum secundum development | GATA4 | |
| Cardiac septum morphogenesis | ACVR1,BMP4,BMP7,CHD7,FZD1,FZD2,GATA4,GATA6,GJA5,HES1,HEY1,HEYL,ISL1,JAG1,MSX2,NRP1,PARVA,PITX2,PROX1,RARB,SMAD6,SMAD7,SOX11,SOX4,TBX3,TGFB2,TGFBR2,ZFPM2 |