Table 3.
Significance and direction of CHD DMRs and background regions in DS versus TD samples
| DMRs | Background regions | |
|---|---|---|
| n (%) | n (%) | |
| Sex combined | ||
| Total | 58 | 5363 |
| Omitted | 0 | 28 |
| p < 0.05 | 16 (27.6) | 995 (18.7) |
| p ≥ 0.05 | 42 (72.4) | 4340 (81.3) |
| Same direction | 34 (58.6) | 3274 (61.4) |
| Opposite direction | 24 (41.4) | 2061 (38.6) |
| Females only | ||
| Total | 341 | 11,998 |
| Omitted | 2 | 147 |
| p < 0.05 | 42 (12.4) | 1101 (9.3) |
| p ≥ 0.05 | 297 (87.6) | 10,750 (90.7) |
| Same direction | 172 (50.7) | 6304 (53.2) |
| Opposite direction | 167 (49.3) | 5547 (46.8) |
| Males only | ||
| Total | 3938 | 127,819 |
| Omitted | 26 | 1413 |
| p < 0.05 | 602 (15.4) | 18,099 (14.3) |
| p ≥ 0.05 | 3310 (84.6) | 108,307 (85.7) |
| Same direction | 3001 (76.7) | 90,954 (72.0) |
| Opposite direction | 911 (23.3) | 35,452 (28.0) |
Same direction indicates methylation is in same direction (hypo or hyper) in DS versus TD as in DS-CHD versus non-CHD