. 2023 Oct 6;22:168. doi: 10.1186/s12943-023-01854-3

Table 5.

Elaboration of antitumor effects of cannabinoids on melanoma and nonmelanoma skin cancer

Cannabinoid Type Tested	Cancer Cell Line Tested	Results
D (9)-tetrahydrocannabinol	BRAF wild-type melanoma cell line CHL-1 BRAF-mutated A375 and SK-MEL-28 melanoma cell lines	Activation of autophagy and apoptosis, loss of cell viability
JWH-133 synthetic cannabinoid	Human melanoma cell line A2058	Activation of CB2 receptors with JWH-133 reduced adhesion of melanoma cells to brain endothelial cells and decreased trans-endothelial migration rate of melanoma cells
THC WIN-55,212–2	Murine melanoma cell line B16 Human melanoma cell line Meljuso	Decreased melanoma cell viability and increased apoptosis in vitro. Decreased tumor cell growth, proliferation, angiogenesis, and metastasis in vivo

Cannabinoid
Type Tested

Cancer Cell
Line Tested

Results

D (9)-tetrahydrocannabinol

BRAF wild-type melanoma cell line CHL-1 BRAF-mutated A375 and SK-MEL-28 melanoma cell lines

Activation of autophagy and apoptosis, loss of cell viability

JWH-133 synthetic cannabinoid

Human melanoma cell line A2058

Activation of CB2 receptors with JWH-133 reduced adhesion of melanoma cells

to brain endothelial cells and decreased trans-endothelial migration rate of

melanoma cells

THC WIN-55,212–2

Murine melanoma cell line B16

Human melanoma cell line Meljuso

Decreased melanoma cell viability and increased apoptosis in vitro. Decreased

tumor cell growth, proliferation, angiogenesis, and metastasis in vivo