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. 2023 Oct 7;20:229. doi: 10.1186/s12974-023-02922-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effects of anti-BAFF antibody 10F4 on glia in adjacent brain tissue. A, B Histopathological immunofluorescence evaluation of IBA1 immunoreactivity revealed no significant change in the immunoreactivity of IBA1 in the cortex adjacent to the areas of meningeal inflammation in the anti-BAFF treatment group compared to the IgG control group. C, D No significant changes were observed in astrocytosis detected by GFAP immunoreactivity in the cortex surrounding the regions of meningeal inflammation. B, D Data were presented as box plots with the center line indicating the median, the box indicating the 25th and 75th percentiles, the whiskers indicating range, (min–max) and the dots representing all data points. The statistical analysis was conducted using Mann–Whitney U-tests, and P-values were derived from it. The significance level was set to *P < 0.05. The scale bars = 100 um