Table 3.

Sensitivity analyses of organic iron content with epigenetic aging accelerations

Exposure	Outcome	Weighted median		MR-egger regression		Heterogeneitya	MR-PRESSO outlier detectb		Pleiotropyc
		Beta (95% CI)	P value	Beta (95% CI)	P value		Beta (95% CI)	P Value
Liver iron content	Grim	0.28 (0.05, 0.50)	1.63E−02	0.27 (− 0.03, 0.56)	1.12E−01	I2 = 0%; Cochrane Q = 8; P = 0.538	No significant outliers		Intercept = -0.003; P = 0.892
Liver iron content	Hannum	0.35 (0.13, 0.57)	2.01E−03	0.42 (0.08, 0.76)	3.97E−02	I2 = 21.1%; Cochrane Q = 11; P = 0.249	No significant outliers		Intercept = -0.014; P = 0.598
Liver iron content	IE	0.39 (0.16, 0.62)	8.75E−04	0.32 (0.02, 0.62)	7.22E−02	I2 = 0%; Cochrane Q = 7; P = 0.520	No significant outliers		Intercept = 0.019; P = 0.421
Liver iron content	Pheno	0.39 (0.09, 0.69)	1.19E−02	0.21 (− 0.36, 0.77)	4.95E−01	I2 = 58.5%; Cochrane Q = 22; P = 0.010	0.43 (0.12, 0.74)	2.54E−02	Intercept = 0.052; P = 0.241
Pancreas iron content	Grim	0.11 (− 0.35, 0.57)	6.35E−01	0.57 (− 0.29, 1.43)	2.10E−01	I2 = 4.2%; Cochrane Q = 22; P = 0.404	No significant outliers		Intercept = -0.029; P = 0.316
Pancreas iron content	Hannum	0.08 (− 0.42, 0.58)	7.46E−01	0.50 (− 0.41, 1.41)	2.96E−01	I2 = 9.9%; Cochrane Q = 23; P = 0.328	No significant outliers		Intercept = -0.030; P = 0.328
Pancreas iron content	IE	0.35 (− 0.30, 1.00)	2.87E−01	0.45 (− 0.84, 1.75)	5.00E−01	I2 = 16.4%; Cochrane Q = 25; P = 0.242	No significant outliers		Intercept = -0.004; P = 0.931
Pancreas iron content	Pheno	0.18 (− 0.29, 0.66)	4.48E−01	0.35 (− 0.51, 1.21)	4.35E−01	I2 = 0%; Cochrane Q = 17; P = 0.715	No significant outliers		Intercept = -0.011; P = 0.701

^aHeterogeneity in the random effect IVW methods was reported

^bMR-PRESSO (NbDistribution = 10,000, P < 0.05)

^cMR-Egger was used to detect pleiotropy. There is no pleiotropy observed among all analyses (P > 0.05)

CI, confidence interval, MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier, IE Intrinsic epigenetic