Table 4.
Description of GWAS statistic included in present study
| Authors | PMID | Traits | Measurement | Data adjustment | Sample size | Sample source | Population | Sex |
|---|---|---|---|---|---|---|---|---|
| Benyamin et al. (the 2014 datasets) | 25352340 | Serum ferritin | Mean, SD | Age, principal component scores and other study specific covariates, for each sex separately, adjustments for each cohort were available in the supplementary of original article | 23,986 (Discovery) + 24,986 (Replication) | Genetics of Iron Status Consortium, the Discovery cohorts were composed of 11 cohorts in 9 participating centers, and 8 additional cohorts for the Replication cohorts | European ancestry | Males and Females |
| 25352340 | Serum iron | |||||||
| 25352340 | Serum transferrin | |||||||
| 25352340 | Transferrin Saturation | |||||||
| Bell et al. (the 2021 datasets) | 33536631 | Serum ferritin | Rank-based inverse normal transformed SD | Adjusted for age using a generalized additive model. Additionally, for UK cohort the biomarkers were adjusted for menopausal status, ABO blood group, BMI, smoking levels, alcohol levels and iron supplementation status | 246,139 | Ice land (deCODE genetics), UK (INTERVAL study) and Denmark (Danish Blood Donor Study) | European ancestry | Males and Females |
| 33536631 | Serum iron | 163,551 | ||||||
| 33536631 | Iron binding capacity | 135,430 | ||||||
| 33536631 | Transferrin saturation | 131,471 | ||||||
| Liu et al. | 34128465 | Liver iron content | Mean, SD | Age at imaging visit, age squared, sex, imaging center, scan date, scan time, and genotyping batch | 11,069 | UK Biobank | European ancestry | Males and females |
| 34128465 | Pancreas iron content | Mean, SD | 5,525 | |||||
| McCartney et al. | 34187551 | GrimAA | Mean, SD | Adjustments for each cohort were available in the supplementary of original article | 34,710 | 29 studies from UK (n = 9), USA (n = 8), Netherlands (n = 3), Finland (n = 2), and Australia (n = 1), Denmark (n = 1), Estonia (n = 1), Germany (n = 1), Italy (n = 1), Sweden (n = 1) and Switzerland (n = 1) | European ancestry | Males and females |
| 34187551 | HannumAA | 34,710 | ||||||
| 34187551 | Horvath (IEAA) | 34,710 | ||||||
| 34187551 | PhenoAA | 34,710 |
SD, standard deviation; GrimAA, GrimAge acceleration; HannumAA, HannumAge acceleration; IEAA, intrinsic epigenetic age acceleration; PhenoAA; PhenoAge acceleration