TABLE 2.
Pregnancy outcome for women exposed to fluoroquinolones during pregnancy compared to that for controls exposed to nonteratogenic antibiotics
Outcome or characteristic | No. of women with the following outcome/ total no. of women:
|
Relative risk (95% confidence interval) | P value | |
---|---|---|---|---|
Quinolone group | Nonteratogenic antibiotic group | |||
Live births | 173/200 | 188/200 | 0.92 (0.86–0.98) | 0.02a |
Spontanous abortion | 18/200 | 10/200 | 1.80 (0.85–3.80) | 0.17a |
Therapeutic abortion | 9/200 | 2/200 | 4.50 (0.98–20.57) | 0.06a |
Vaginal delivery | 145/173 | 148/188 | 1.06 (0.96–1.18) | 0.27a |
Premature birth | 11/173 | 13/188 | 0.92 (0.42–2.00) | 0.99a |
Birth weight, <2,500 g | 7/173 | 9/188 | 0.85 (0.32–2.22) | 0.93a |
Fetal distress | 22/173 | 27/188 | 0.89 (0.52–1.49) | 0.76a |
Delivery by cesarean section | 28/173 | 40/188 | 0.83 (0.61–1.13) | 0.21a |
Gestational age | 39.3 ± 2.0b | 39.8 ± 2.0b | 0.02c | |
Birth weight | 3,452 ± 537d | 3,477 ± 608d | 0.92c |
χ2 test (with Yates correction).
Units are in weeks of gestation.
Mann-Whitney rank sum test.
Units are in grams.