Table 1.
Activities and mechanism of Nrf2 in digestive system cancers.
| Tumor type | Cell lines | Signaling pathway | Effects | Reference |
|---|---|---|---|---|
| Colorectal cancer | HT-29 cells HCT116 cells, HT29 cells, SW620 cells |
Nrf2/ARE NF-κB/Nrf2 |
Protective effect of ShaoYao decoction on colitis-associated colorectal cancer by inducing Nrf2 signaling pathway Cyanidin Chloride induces apoptosis by inhibiting NF-κB signaling through activation of Nrf2 in colorectal cancer cells |
(44) (49) |
| Gastric cancer | BGC-823 cells AGS cells, MGC-803 cells |
Nrf2/HO-1 Keap1/Nrf2 |
Nrf2/HO-1 axis regulates the angiogenesis of gastric cancer via targeting VEGF TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/Nrf2 in gastric cancer |
(52) (71) |
| Hepatocellular carcinoma | Huh7 cells, H22 cells HepG2 cells |
Keap1/Nrf2/ARE Keap1/Nrf2 |
Nrf2 down-regulation by camptothecin favors inhibiting invasion, metastasis and angiogenesis in hepatocellular carcinoma Protective effects of raspberry on the oxidative damage in HepG2 cells through Keap1/Nrf2-dependent signaling pathway |
(59) (61) |
| Pancreatic cancer | Panc-1 cells, Canpan-2 cells Panc-1 cells, MiaPaCa-2 cells |
Nrf2-ROS p62/Keap1/Nrf2 |
Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway HEATR1 deficiency promotes pancreatic cancer proliferation and gemcitabine resistance by up-regulating Nrf2 signaling |
(64) (65) |
| Esophageal squamous cell carcinoma | TE-5TE-8 cells, TE-11R cells KYSE 30 cells, KYSE 150 cells, KYSE 450 cells, KYSE 410 cells, KYSE 510 cells, TE-1 cells |
Nrf2/NQO1 Nrf2/SLC7A11 |
Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma SLC7A11 regulated by Nrf2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis |
(67) (72) |