Table 2.

Activities and mechanism of Nrf2 in urinary system cancers.

Tumor type	Cell lines	Signaling pathway	Effects	Reference
Prostate cancer	LNCap cells, PC3 cells, DU145 cells, PrEC cells LNCaP cells DU145 cells RWPE-1 cells, PC3 cells	NF-κB/Nrf2 Nrf2/ARE Keap1/Nrf2/ARE Nrf2/NF-κB	Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF-κB/Nrf2 signaling pathway High glucose promotes prostate cancer cells apoptosis via Nrf2/ARE signaling pathway p62 promotes proliferation,apoptosis-resistance and invasion of prostate cancer cells through the Keap1/Nrf2/ARE axis Nrf2 antioxidant pathway and apoptosis induction and inhibition of NF-κB-mediated inflammatory response in human prostate cancer PC3 cells by Brassica oleracea var. acephala: An in vitro study	(73) (74) (76) (94)
Bladder cancer	T24 cells, RT4 cells, 5637 cells, TCCSUP cells, 253J cells, SV-HUC‐1 cells, SW780 cells	p62/Keap1/Nrf2	p62 promotes bladder cancer cell growth by activating Keap1/Nrf2-dependent antioxidative response	(80)
Renal cell carcinoma	786-0 cells 786‐O cells, OS-RC-2 cells, Caki-1 cells, 769-P cells, A498 cells, ACHN cells, HK-2 cells	Nrf2/ARE Nrf2/TRIM24	Effect of the Nrf2-ARE signaling pathway on biological characteristics and sensitivity to sunitinib in renal cell carcinoma BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma	(93) (95)