Table 3.

Activities and mechanism of Nrf2 in female reproductive system cancers.

Tumor type	Cell lines	Signaling pathway	Effects	Reference
Endometrial cancer	RL95-2 cells SPEC-2 cells	Nrf2/AKR1C1 Keap1/Nrf2	Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway High levels of Nrf2 determine chemoresistance in type II endometrial cancer	(97) (99)
Ovarian cancer	HO8910PM cells, A2780 cells, SKOV3 cells, ES2 cells A2780 cells	Keap1/Nrf2 Nrf2/ABCF2	Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells	(105) (111)
Cervical cancer	C33A cells, HeLa cells, SiHa cells HeLa cells	Nrf2/NQO1/GSH MBNL1/Nrf2	Role of Nrf2 cascade in determining the differential response of cervical cancer cells to anticancer drugs: an in vitro study MBNL1 regulates resistance of HeLa cells to cisplatin via Nrf2	(108) (112)