Table 4.
Activities and mechanism of Nrf2 in other cancers.
| Tumor type | Cell lines | Signaling pathway | Effects | Reference |
|---|---|---|---|---|
| Breast cancer | MDA-MB-231 cells, MCF-7 cells MDA-MB-231 cells, MCF-7 cells MCF-10A cells, MDA-MB-231 cells, MCF-7 cells MCF-7 cells |
Nrf2/HO-1 Nrf2/G6PD/HIF-1α Nrf2/HIF-1α Nrf2/ARE |
Levistilide A induces ferroptosis by activating the Nrf2/HO-1 signaling pathway in breast cancer cells Nrf2 promotes breast cancer cell migration via up-regulation of G6PD/HIF-1α/Notch1 axis Nrf2 facilitates breast cancer cell growth via HIF-1α-mediated metabolic reprogramming Effect of miR-101 on proliferation and oxidative stress-induced apoptosis of breast cancer cells via Nrf2 signaling pathway |
(117) (119) (121) (123) |
| Lung cancer | SQ-19 cells, H2126 cells, H1437 cells, H1395 cells, A549 cells NCI-H1299 cells, NCI-H460 cells |
Keap1/Nrf2 Nrf2/ARE |
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth Nrf2/ARE pathway activation is involved in negatively regulating heat-induced apoptosis in non-small cell lung cancer cells |
(155) (156) |
| Glioblastoma | T98G cells U251 cells U87MG cells, U251 cells |
Nrf2/ABCC1/MRP1 Nrf2/MMP9 AKT/Nrf2/HO-1 |
High levels of Nrf2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation The role of Nrf2 in migration and invasion of human glioma cell U251 The E3 ubiquitin ligase NEDD4-1 mediates temozolomide-resistant glioblastoma through PTEN attenuation and redox imbalance in Nrf2-HO-1axis |
(140) (157) (158) |
| Osteosarcoma | HOS cells, Saos-2 cells, 143B cells, U2OS cells, MG63 cells, hFOB 1.19 cells MG63 cells |
Nrf2/TRIM22 AMPK/Nrf2 |
TRIM22 inhibits osteosarcoma progression through destabilizing Nrf2 and thus activation of ROS/AMPK/mTOR/autophagy signaling Tanshinone IIA inhibits osteosarcoma growth through modulation of AMPK-Nrf2 signaling pathway |
(147) (159) |
| Leukemia | HL-60 cells, THP-1 cells THP-1 cells, U937 cells, MV4-11 cells |
Nrf2/STAT3 Nrf2/RFC4 |
LncRNA GAS5 induces cell apoptosis in acute myeloid leukemia by targeting Nrf2 Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4 |
(150) (160) |