Table 1.
Basic information of exposure and outcome groups in the study.
| Outcome factor |
Exposure factors |
N of SNPs | Description | ||||
|---|---|---|---|---|---|---|---|
| Trait | Group ID | Database | Trait | Group ID | Database | ||
| Failure and rejection of transplanted organs and tissues | finn-b-ST19_ FAILU_ REJEC_ TRANSPLANTED _ORGANS_TISSU |
FinnGen biobank analysis round 5 | LDL | met-d-LDL_C (N of population = 115,078) | Metabolic biomarkers in the UK Biobank measured by Nightingale Health 2020 | 12,321,875 | LDL cholesterol |
| met-d-Clinical_LDL_C (N of population = 115,078) | 12,321,875 | Clinical LDL cholesterol | |||||
| ieu-b-4846 (N of population = 70,814) | GWAS summary datasets generated by many different consortia that have been manually collected and curated, initially developed for MR-Base (round 2) | 7,892,997 | LDL cholesterol | ||||
| HDL | met-d-HDL_C (N of population = 115,078) | Metabolic biomarkers in the UK Biobank measured by Nightingale Health 2020 | 12,321,875 | HDL cholesterol | |||
| ukb-d-30760_irnt (N of population: not shown) |
Neale lab analysis of UK Biobank phenotypes, round 2 |
13,585,298 | HDL cholesterol | ||||
| ieu-b-109 (N of population = 403,943) | GWAS summary datasets generated by many different consortia that have been manually collected and curated, initially developed for MR-Base (round 2) | 12,321,875 | HDL cholesterol | ||||
| Cholesterol | met-d-Total_C (N of population = 115,078) | Metabolic biomarkers in the UK Biobank measured by Nightingale Health 2020 | 12,321,875 | Total cholesterol | |||
| ukb-d-30690_irnt (N of population: not shown) | Neale lab analysis of UK Biobank phenotypes, round 2 | 13,586,045 | Cholesterol | ||||
| ukb-b-10912 (N = 462,933) | IEU analysis of UK Biobank phenotypes | 9,851,867 | Non-cancer illness code, self-reported: high cholesterol | ||||
| Triglyceride | met-d-Total_TG (N of population = 115,078) | Metabolic biomarkers in the UK Biobank measured by Nightingale Health 2020 | 12,321,875 | Total triglycerides | |||
| met-c-934 (N of population = 21,545) | Circulating metabolites analyzed by Kettunen et al., 2016 | 11,871,391 | Serum total triglycerides | ||||
| ieu-b-111 (N of population = 441,016) | GWAS summary datasets generated by many different consortia that have been manually collected and curated, initially developed for MR-Base (round 2) | 12,321,875 | Triglycerides | ||||
HDL, High Density Lipoprotein; LDL, Low Density Lipoprotein; TG, Triglyceride; N, number.