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Isolation of S-1153 and nevirapine resistant variants in vitro
| Drug | Emergence of resistant mutants
|
Amino acid substitution in RT | |
|---|---|---|---|
| No. of passages | No. of days of culture | ||
| S-1153 | >9 | >31 | K103T + V106A + L234I, V106A + F227L |
| Nevirapine | 2–3 | 7–10 | Y181C, V106A |
