TABLE 5.
Sensitivities of molecular clones with RT gene mutations to S-1153 and other anti-HIV agentsa
| Virus mutation | EC50 (ng/ml)
|
|||
|---|---|---|---|---|
| S-1153 | Nevirapine | Delavirdine | Loviride | |
| Wild type (strain NL432) | 0.31 ± 0.07 | 6.8 ± 2.1 | 5.9 ± 2.1 | 6.3 ± 0.5 |
| L100I | 0.94 ± 0.18 | 14 ± 12 | >500 | 5.4 ± 3.4 |
| K103N | 0.31 ± 0.14 | 300 ± 170 | 460 ± 80 | 140 ± 60 |
| V106A | 1.4 ± 0.9 | >500 | 150 ± 50 | 100 ± 40 |
| Y181C | 4.2 ± 1.9 | >500 | >500 | >500 |
| Y188C | 0.46 ± 0.17 | >500 | 32 ± 7 | 230 ± 140 |
| G190A | 0.34 ± 0.07 | >500 | 1.3 ± 0.3 | 250 ± 110 |
| F227C | 2.4 ± 1.1 | 87 ± 32 | 9.6 ± 5.1 | 58 ± 29 |
| F227L | 0.46 ± 0.05 | 28 ± 5 | 0.78 ± 0.48 | 23 ± 7 |
| L234I | 6.8 ± 4.2 | 3.5 ± 1.5 | 13 ± 8 | 0.45 ± 0.24 |
| P236L | 1.1 ± 0.1 | 21 ± 1 | >500 | 2.8 ± 0.4 |
| V106A + Y181C | 2.5 ± 0.2 | >500 | >500 | >500 |
| V106A + F227L | 120 ± 10 | >500 | 37 ± 2 | >500 |
a
Each value represents the mean ± standard deviation for at least three experiments, each of which was performed in duplicate.