Table 2.

The role of identified IRGs in cancer pathology.

Identified genes	Roles in cancer pathology
ARNTL	Promoting apoptosis and inhibiting cell viability via autophagy in oral cancer [24]; Suppressing cell proliferation and enhancing sensitivity to cisplatin in ovarian cancer cells [25] and nasopharyngeal carcinoma by activating CDK5 [26]
GSDMD	Highly expressed in bladder cancer tissue and linked with a higher risk of local tumor recurrence [27]
IRX3	Regulating the differentiation of Wilms tumor by activating WNT/β-catenin-signalling [28]; Enhancing the morphologic and phenotypic differentiation block of acute myeloid leukemia cells [29]
N4BP2L1	Promoting oral squamous cell carcinoma invasion by activating miR-448 [30]
NUB1	Inhibiting proliferation and invasion of gastric cancer cells through upregulation of p27Kip1 and inhibition of epithelial-mesenchymal transition [31]; Exerting IFN-a induced antimitogenic function in renal cell carcinoma [32]
PARP11	Downregulating type I interferon receptor and promoting immunosuppression in the TME [33]
HAPLN3	Highly expressed in breast cancer tissue and positively correlated to human epidermal receptor 2 level [34]