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. 2023 Aug 21;41(5):727–736. doi: 10.1007/s10637-023-01388-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Survival analysis. Kaplan-Meier plots with CI95% (dashed lines) for OS and PFS dichotomized by the cross-validated cut-off points for on-treatment CRP in mg/dl (a, d), CRP kinetics (b, e), on-treatment NLR (c, f) levels are shown. Log-rank testing was used for comparison of the survival curves. Abbreviations: CI95%, 95% confidence interval; CRP, C-reactive protein; cvAUROC, cross-validated area under the receiver operating curve; NLR, neutrophil-to-lymphocyte ratio; OS, overall survival; PFS, progression-free survival